Please crosspost this Buster Alert as widely as possible. 
It is my hope that the term "Buster Alert" will take it's place right 
Alongside "Amber Alert" as something to be noticed. Thankfully, I am not alone in 
This crusade but you'll hear more from the others later. When you do, if you 
Have the stomach for it, you also will learn about Buster's ordeal. 
Suffice it to say for right now that the mission, undertaken in Buster's name, is 
To make a difference in the health and welfare of other herding breed dogs, 
Just like Amber did for children everywhere. 
Folks, you all need to know this yesterday, not tomorrow: IT'S NOT JUST 
IVERMECTIN!! 
Molecular biological research is proving that many herding breed dogs suffer 
A genetic flaw called MDR1 - multiple drug resistance deficiency. In sum, 
The barrier (P-glycoprotein) that protects the brain by transporting a variety 
Of drugs from the brain tissues back into the capillaries is flawed. This 
Is the root cause of the disastrous neurological effects, including death, 
Caused by the ingestion of Ivermectin. But, IT'S NOT JUST IVERMECTIN (also 
Known as Avermectin, and the anti-parasitic used in the trade name drug 
Heartguard and commonly used to treat demodic mange). 
It's also almost certainly these drugs (alternate names, common usage, and 
Trade names follow the generic name): 
Metronidazole (diarrhea and giardia)
Flagyl; Rozex; Metrogel
Butorphanol (pain relief after spay/neuter; cough suppressant and canine flu)
Torbutol; Butorphic; Dolorex; Morphasol; Turbogesic
Acepromazine (tranquilizer/calming agent and pre-anesthetic)
Ace; ACP; Atravet
Cyclosporine or Ciclosporin (allergy treatment/immunosuppresant)
Sandimmune; Neoral; Cicloral; Gengraf; Restasis
Vinblastine and Vincristine (chemotherapy for cancers & leukemia)
Cancer regimens called CHOP and Stanford V 
Doxurobicin or Adriamycin or Hydroxyldaunorubicin (chemotherapy for cancers 
& leukemia)
Doxil; cancer regimens called ABVD, CHOP, and FAC
Loperamide (diarrhea)
Imodium; Lopex; Dimor; Pepto
Digoxin (heart ailments)
Digitalis (Foxglove) family 

Additionally, neurotoxicity in dogs with the MDR1 genetic flaw is suspected 
To have been caused by: 
Ondansetron (nausea and vomiting)
Zofran; Emeset; Emetron; Ondemet 
Domperidone (nausea, vomiting, and to stimulate lactation)
Motilium
Paclitaxel (cancer)
Taxol; Abraxane
Mitoxantrone (cancer/leukemia)
Etoposide (cancer/leukemia)
Eposin; Etopophos; Vepeside; VP-16
Rifampicin or Rifampin (antibiotic - infections, influenza, pneumonia, 
Staph, meningitis)
Rifadin; Rifater; Rimactane; Rifinah; Rimactazid
Quinidine (heart)
Morphine (pain relief, anesthesia, cough suppressant, anti-diarrheal, 
Shortness of breath) 
Although any errors or omissions in the above are solely my doing , the 
Credit for most of this information goes to: 
Washington State University College of Veterinary Medicine 
Veterinary Clinical Pharmacology Laboratory
PO Box 2280
Pullman, WA 99165-2280
(Phone/FAX 509-335-3745)
VCPL@vetmed.wsu.edu 
You can learn more about the MDR1 defect and about testing your herding 
Breed dog by going to their website:
_http://www.vetmed.wsu.edu/depts-VCPL/ _ 
(http://www.vetmed.wsu.edu/depts-VCPL/") 
PLEASE PLEASE PLEASE 
Do not leave it up to your vet to know this ... YOU must print this out 
And know about MDR1 ... It IS a matter of life or death. 
And, again, please cross-post widely. It's also not just Aussies - affected 
Breeds include Collies, 
Shetland Sheepdogs (Shelties), Australian Shepherds, Old English Sheepdogs, 
German Shepherds, Long-haired Whippets, Silken Windhounds, Skye Terriers, and 
A variety of mixed breed dogs.